1 sanctum, shrine, chapel, temple, church, house of worship, house of God; synagogue, mosque, pagoda:
All of us retire at this time to the sanctuary for evening prayer.
2 asylum, refuge, retreat, protection, shelter, safety:
Formerly, criminals could seek sanctuary in churches.
3 (nature or wildlife) reserve or preserve, reservation, conservation area, national park:
If housing is built here, it will destroy the bird sanctuary.