1 hole, perforation, opening, leak; flat (tyre):
I haven't the tools needed to patch the puncture in the tyre.
2 perforation, perforating, holing, puncturing, piercing, stabbing, punching:
The puncture of the balloon means that we shall have to postpone our trip.
3 perforate, hole, pierce, stab, penetrate, go through, prick, nick, rupture:
An arrow punctured the side of the tent.
4 deflate, disillusion, bring up short, discourage, humble, dash, destroy, ruin:
Any hopes I had of winning the marathon were punctured when I tripped and fell, spraining my ankle.