1 quit, run away or off, escape, get away, fly, take flight, bolt, go (away), decamp, abscond, seek safety, avoid, make off, make an exit, make (good) one's escape, make a (clean) getaway, beat a (hasty) retreat, take to one's heels, show a clean pair of heels, turn tail, make tracks, make a run for it, cut and run, vanish, disappear, Brit levant, Colloq take off, scoot, make oneself scarce, beat it, clear out, fly the coop, skedaddle, scram, Brit scarper, Australian and New Zealand shoot through, US and Canadian take a (run-out) powder, skip (town), cut out, hightail it, Old-fashioned skiddoo; Slang split, Brit bugger off, do a moonlight flit, do a bunk, US and Canadian vamoose, lam out, take it on the lam, blow, bail out:
He fled the town and was never seen again. When they saw what they had done, they fled. She fled to Brazil to avoid the tax authorities.
2 avoid, evade, shun, escape from, eschew:
She fled the responsibilities of caring for her children.