1 use (up), expend, consume, finish, deplete, spend, dissipate, run through, squander, waste, fritter away, Slang blow:
In less than a year, he had exhausted all his funds.
2 tire (out), fatigue, weary, wear out, enervate, fag, overtire, sap, strain, tax, weaken, prostrate, debilitate, disable, Colloq frazzle:
Working sixty hours a week would exhaust anyone.
3 empty, drain, evacuate, void, clean or clear out:
The pump is used to exhaust the chamber of air.
4 overdo, overwork, treat thoroughly, deplete, drain, empty:
I think we've exhausted that topic.
5 empty (out), drain (off or out), vent, issue, escape, discharge, run out:
The fumes exhaust through this tube.
6 emanation, effluent, emission, fumes, gas:
Car exhausts are polluting the atmosphere.