1 anguish, anxiety, affliction, angst, grief, misery, torment, ache, pain, suffering, agony, torture, woe, woefulness, wretchedness; unhappiness, sorrow, sadness, depression, heartache, desolation:
It is impossible to imagine the distress of a bereaved parent.
2 calamity, trouble, adversity, catastrophe, tragedy, misfortune, difficulty, hardship, straits, trial, disaster:
Has he no sympathy for the distresses that have beset his people?
3 bother, disturb, perturb, upset, trouble, worry, harrow, harry, vex, harass, plague, oppress, grieve, torment, torture, afflict:
The thought of Miss Camberley as a hostage distressed us all.