distracted, agitated, troubled, disturbed, upset, perturbed, wrought or worked up, excited, frantic, at (one's) wits' end, overwrought, frenetic, nervous, frenzied, feverish, wild, hysterical, delirious, irrational, crazy, mad, insane, berserk, run(ning) amok:
He is distraught with grief.
appear, be, look, seem, sound
She sounded absolutely distraught.
| become | remain
Weeks after the accident she remained distraught.
| leave sb
His mother's death left him utterly distraught.
extremely, really, terribly, very | absolutely, completely, quite, utterly
They were terribly distraught at the news of his accident.
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