1 meant, intended, designed, predetermined, foreordained, predestined, fated; doomed, written; US in the cards:
His destined end was to be shot while escaping. Oliver was destined to fail at everything he tried. It was destined that the boy would become king.
2 certain, sure, bound, ineluctable, unavoidable, inevitable, inescapable:
Being devoured by monsters is the destined demise of all who dare to enter there.