So full is the world of calamity that every source of pleasure is polluted.
Advanced English Dictionary
+noun [C, U] (plural calamities) an event that causes great harm or damage Synonym: DISASTER Sudan suffered a series of calamities during the 1980s. + His financial help saved the magazine from total calamity.
Random quote: To free us from the expectations of others, to give us back to ourselves... there lies the great, singular power of self-respect.: Joan Didion